Generico Endep

1. Denomination

Elavil, Endep

2. Active Substance

Amitriptyline Hydrochloride

3. Indications for Use.

Depressions, schizophrenic insanities, worried depressions of various characters, mixed emotional disorders, behavioral disorders, inadequate shaking of various parts of the body on the basis of emotional illnesses, night incontinence of urine (auxiliary treatment), severe neurogenic pains, prevention of migraine.

4. Action

The drug decreases physic tension in worried depressions, eliminates the events of fear and oppression. Antidepressive performance is developing during 2–3 weeks after the beginning of the treatment.

5. Posology and Administration

The drug should be used strongly on doctor’s order.
The drug is administered orally (during meal or after it).
The starting daily oral dose is 50-75 mg (25mg in 2-3 intakes), and then the dose is being gradually increased by 25-50 mg up to the desired anti-depressive outcome. The optimal daily dose is 150-200 mg (maximal part of the dose is to be taken before night sleep).
After a sustainable anti-depressive performance has been received the doses are to de reduced gradually and slowly in 2-4 weeks. In cases of the emergence of signs of depression while the doses are being reduced it is necessary to resume the previous dose.
In elderly patients in mild impairments the doses are 25-50-100 mg (maximally) in divided doses or once daily before night sleep. For the prevention of migraine, chronic Neutrogena pains (including long-lasted headaches) it is used from 12,5-25 mg to 100 mg daily.
Day drowsiness may be reduced by the reduction of the drug’s dose and by the earlier evening intake.
In order to avoid a cancellation syndrome a drug therapy should not be interrupted abruptly, a dose of the drug should be reduced gradually during one or two weeks.
Children more than 6 years of age are to be administered individually and under strict supervision of doctor!

6. Counterindications

Heart failure, acute period of infarction and that of rehabilitation, asequence of cardiac muscle, high arterial tension. Acute diseases of liver and kidneys with frank disorder of their functions, gastric and duodenal ulcer in aggravation stage. Increase in size of the prostate gland, thickening of the walls of urinary bladder, native disorders of the stomach performance, paralytic ileus. Pregnancy, breatfeeding period, childhood under 6 years of age.
Hypersensitivity to Amitriptyline.

7. Should Be Taken with Precautions, if…

Caution should be taken while using Amitriptyline in people suffering from alcoholic addiction, bronchial asthma, manic-depressive insanity and epilepsy, also in depression of marrowy blood formation, diseases of thyroid gland, stenocardia and heart failure and in disorders of visual organs.
The medicine should not be administered to manic patients and to patients with suicidal inclinations. Care should be taken while using in thrombosis, arrhythmias and heart failure. During the treatment alcoholic beverages use should be avoided.

8. Interface with Other Medications

In the period of Amiltriptyline therapy it is categorically prohibited to combine its therapy with some other medication, because in some cases it may result in lethal outcome!

9. Overdosing

Symptoms: hallucinations, convulsions, coma, disorders of cardio-conductibility, extracystole, ventricular arrhythmias, excessive sweat, confused mental state.

10. Side Effects

Drowsiness, dizziness, disorders of vision, heartburn, dry mouth, nausea, agitation, headache, skin rash, desudation, pin sensation in hands, tachycardia, retention of urination, constipations. It may result in the activation of quietly proceeding schizophrenia. Allergic reactions: skin rash and others.

11. Pregnancy and Lactation

The drug is prohibited for the period of pregnancy and breastfeeding.

12. Driving

The drug may provoke drowsiness, that is why it is counterindicated to the persons whose activity is connected with elevated concentration of attention, coordination of movements and with heightened danger (driving vehicles, work with heavy things etc.).

ANTI-DEPRESSANTS
These are drugs which are designed to lift the mood in depressive illness. Many people confuse them with tranquillizers, such as Valium and Librium, but in fact they are not related in any way at all.
Anti-depressants work by altering the levels of concentration of various natural brain chemicals, since it is thought that an imbalance of these chemicals lies behind most cases of depression.
They are not at all addictive, as some patients fear, but they are powerful agents and it is very important that you stick to the dose that your physician has prescribed. It is also vital that you keep these potentially lethal drugs out of the hands of any children in your home.
ANTI-DEPRESSANTS/SLEEPING AID

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